What Do I Need to Know About Zepbound?

Weight loss drugs exploded in popularity over the past year and now there’s one more to add to the mix. The Food and Drug Administration(FDA) just approved the injectable drug Zepbound (tirzepatide) for adults who have obesity or overweight. With more and more medications claiming to aid with weight loss coming to market, it’s normal to wonder: What is Zepbound?

Two randomized, double-blind, placebo-controlled trials (per the FDA) of 2,519 adults with obesity or overweight found that those who took Zepbound had a statistically significant reduction in body weight compared to those who took a placebo. The FDA also notes that those who took the highest dose of Zepbound in one trial lost an average of 18% of their body weight during the study. (Patients who had type 2 diabetes lost an average of 12% of their body weight.)

“Obesity and overweight are serious conditions that can be associated with some of the leading causes of death such as heart disease, stroke, and diabetes,” John Sharretts, M.D., director of the Division of Diabetes, Lipid Disorders, and Obesity in the FDA’s Center for Drug Evaluation and Research, said in a statement. “In light of increasing rates of both obesity and overweight in the United States, today’s approval addresses an unmet medical need.”

Excerpted from Prevention

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