Is the Next Ozempic Almost Here?

A Tufts team is pushing weight loss science forward with a four-in-one hormone drug designed to deliver lasting, surgery-level results without the same drawbacks. Credit: Shutterstock

Weight loss drugs like Ozempic and Wegovy are used by over 15 million adults in the U.S., or 4.5% of the population. Despite their effectiveness, they have drawbacks. Their effect may not last after discontinuing use, and side effects including osteoporosis and muscle loss have raised concerns about long-term harms. They also induce nausea, which can make it difficult to stay the course of treatment.

Now Tufts researchers led by Krishna Kumar, Robinson Professor of Chemistry, have designed a new, next-generation compound with hopes that it could be more effective with fewer side effects, which they report in a paper in the Journal of the American Chemical Society.

Excerpted from Science Daily

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