Which Weight Loss Drugs Cause the Most Weight Loss?

Injectable prescription drugs that reduce appetite — like Ozempic, Saxenda and Mounjaro — have skyrocketed in popularity in recent years. Now, Cleveland Clinic researchers may have figured out which patients have the best odds of success. Women who take Wegovy to treat obesity have the greatest likelihood of achieving 10% or more weight loss in a year, according to a study published Friday in JAMA Network Open.

“We found that long-term weight reduction varied significantly based on the medication’s active agent, treatment indication, dosage and persistence with the medication,” said Dr. Hamlet Gasoyan, lead study author and a researcher with Cleveland Clinic’s Center for Value-Based Care Research.

The researchers only studied two types of drugs that mimic the GLP-1 hormone to make people feel fuller for longer — semaglutide and liraglutide. Semaglutide is sold as Ozempic to treat Type 2 diabetes and as Wegovy for obesity.

Excerpted from The New York Post

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