Does Exercise Still Matter When Using GLP-1 Medications?
A new publication underlines the importance of nutrition and physical activity to ensure patients are successful in their weight loss journeys.
In it, researchers from Mass General Brigham provide advice to reduce side effects, protect muscle health, and ensure sufficient nutrient intake for patients taking GLP-1 medications such as semaglutide (sold as Wegovy for weight loss) or tirzepatide (Zepbound). The authors emphasize that GLP-1 medications can lead to substantial weight loss, ranging from 15% to 21%. Yet, diet and lifestyle factors remain critically important for optimal results.
“Many patients lose muscle mass (in addition to fat mass) and have GI symptoms that lead to stopping medication,” said senior author JoAnn E. Manson, MD, DrPH, chief of the Division of Preventive Medicine at Brigham and Women’s Hospital, a founding member of the Mass General Brigham health care system. “We propose an approach to improving outcomes on GLP-1s by preserving lean body mass, ensuring good nutrition, and managing symptoms that can otherwise lead to stopping medications.”
Excerpted from Mass General Brigham
