Can a New Pill Burn Fat Without Suppressing Your Appetite?
AN EXPERIMENTAL OBESITY pill that works in a different way from the wildly popular Ozempic may help people lose weight, according to results from a small, preliminary human trial.
Ozempic and other GLP-1 drugs reduce food intake by stimulating a feeling of fullness. They act on the brain to promote satiety and on the gut to slow the movement of food through the stomach, helping people feel full longer. As a result, people on the drugs lose weight because they eat less.
But a new drug may be able to burn energy, and thus fat, without reducing appetite. In a Phase I trial described in the journal Nature Metabolism, the drug led to statistically significant weight loss in participants after two weeks. Dubbed SANA, the drug is derived from salicylate, a compound used to make aspirin. Developed by Eolo Pharma of Montevideo, Uruguay, it activates a pathway called creatine-dependent thermogenesis.
Excerpted from Wired
